Targeting the Tumor Microenvironment through mTOR Inhibition and Chemotherapy as Induction Therapy for Locally Advanced Head and Neck Squamous Cell Carcinoma: The CAPRA Study

SIMPLE SUMMARY: The PI3K-AKT-mTOR pathway is dysregulated in 70% of head and neck squamous cell carcinoma (HNSCC) and linked to the tumor microenvironment. This weekly induction treatment combined the mTOR inhibitor everolimus with carboplatin-paclitaxel chemotherapy for locally advanced T3-4/N0-3 H...

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Detalles Bibliográficos
Autores principales: Evrard, Diane, Dumont, Clément, Gatineau, Michel, Delord, Jean-Pierre, Fayette, Jérôme, Dreyer, Chantal, Tijeras-Raballand, Annemilaï, de Gramont, Armand, Delattre, Jean-François, Granier, Muriel, Aissat, Nasredine, Garcia-Larnicol, Marie-Line, Slimane, Khemaies, Chibaudel, Benoist, Raymond, Eric, Le Tourneau, Christophe, Faivre, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496893/
https://www.ncbi.nlm.nih.gov/pubmed/36139669
http://dx.doi.org/10.3390/cancers14184509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496893/
https://www.ncbi.nlm.nih.gov/pubmed/36139669
http://dx.doi.org/10.3390/cancers14184509

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