Cargando…

The Biological and Clinical Consequences of RNA Splicing Factor U2AF1 Mutation in Myeloid Malignancies

SIMPLE SUMMARY: U2 small nuclear RNA auxiliary factor 1 (U2AF1) is one of the most important RNA splicing genes involved in regulating the alternative splicing of pre-mRNA. U2AF1 mutation is a genetic driver event in the initiation of myelodysplastic syndromes (MDSs) and frequently occurs in myeloid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Yangjing, Cai, Weili, Hua, Ye, Yang, Xiaochen, Zhou, Jingdong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496927/ https://www.ncbi.nlm.nih.gov/pubmed/36139566 http://dx.doi.org/10.3390/cancers14184406

Ejemplares similares

U2AF1 mutations alter splice site recognition in hematological malignancies
por: Ilagan, Janine O., et al.
Publicado: (2015)

RNA structure replaces the need for U2AF2 in splicing
por: Lin, Chien-Ling, et al.
Publicado: (2016)

RECURRENT MUTATIONS IN THE U2AF1 SPLICING FACTOR IN MYELODYSPLASTIC SYNDROMES
por: Graubert, Timothy A., et al.
Publicado: (2011)

U2AF1 Mutations Alter Sequence Specificity of pre-mRNA Binding and Splicing
por: Okeyo-Owuor, Theresa, et al.
Publicado: (2014)

A splice site-sensing conformational switch in U2AF2 is modulated by U2AF1 and its recurrent myelodysplasia-associated mutation
por: Warnasooriya, Chandani, et al.
Publicado: (2020)

The consequences of cohesin mutations in myeloid malignancies
por: Bhattacharya, Shubhra Ashish, et al.
Publicado: (2023)

Control of Pre-mRNA Splicing by the General Splicing Factors PUF60 and U2AF(65)
por: Hastings, Michelle L., et al.
Publicado: (2007)

Splice site m(6)A methylation prevents binding of U2AF35 to inhibit RNA splicing
por: Mendel, Mateusz, et al.
Publicado: (2021)

Signal-Regulated Pre-mRNA Occupancy by the General Splicing Factor U2AF
por: Tisserant, Anne, et al.
Publicado: (2008)

Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF1
por: Yoshida, Hisashi, et al.
Publicado: (2020)

U2AF1 Mutations in Chinese Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome
por: Qian, Jun, et al.
Publicado: (2012)

Targeting of U2AF(65) to Sites of Active Splicing in the Nucleus
por: Gama-Carvalho, Margarida, et al.
Publicado: (1997)

An extended U2AF(65)–RNA-binding domain recognizes the 3′ splice site signal
por: Agrawal, Anant A., et al.
Publicado: (2016)

The U2AF1(S34F) mutation induces lineage-specific splicing alterations in myelodysplastic syndromes
por: Yip, Bon Ham, et al.
Publicado: (2017)

Identification of U2AF(35)-dependent exons by RNA-Seq reveals a link between 3′ splice-site organization and activity of U2AF-related proteins
por: Kralovicova, Jana, et al.
Publicado: (2015)

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival
por: Fei, Dennis Liang, et al.
Publicado: (2016)

Promoter R-Loops Recruit U2AF1 to Modulate Its Phase Separation and RNA Splicing
por: He, Xiaomei, et al.
Publicado: (2023)

U2AF1 in various neoplastic diseases and relevant targeted therapies for malignant cancers with complex mutations (Review)
por: Nian, Qing, et al.
Publicado: (2023)

Expression and prognosis analysis of TET family in acute myeloid leukemia
por: Zhang, Tingjuan, et al.
Publicado: (2020)

Alternative Splicing in Myeloid Malignancies
por: Gurnari, Carmelo, et al.
Publicado: (2021)

Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65
por: Sun, Xin, et al.
Publicado: (2015)

Two Arabidopsis Splicing Factors, U2AF65a and U2AF65b, Differentially Control Flowering Time by Modulating the Expression or Alternative Splicing of a Subset of FLC Upstream Regulators
por: Lee, Hee Tae, et al.
Publicado: (2023)

U2AF1 pathogenic variants in myeloid neoplasms and precursor states: distribution of co-mutations and prognostic heterogeneity
por: Badar, Talha, et al.
Publicado: (2023)

Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal
por: Glasser, Eliezra, et al.
Publicado: (2022)

HNRNPA1 promotes recognition of splice site decoys by U2AF2 in vivo
por: Howard, Jonathan M., et al.
Publicado: (2018)

Mutations in the Caenorhabditis elegans U2AF Large Subunit UAF-1 Alter the Choice of a 3′ Splice Site In Vivo
por: Ma, Long, et al.
Publicado: (2009)

Consequences of the AF-2 incident in Japan.
por: Tazima, Y
Publicado: (1979)

Mutations in Splicing Factor Genes in Myeloid Malignancies: Significance and Impact on Clinical Features
por: Visconte, Valeria, et al.
Publicado: (2019)

Molecular Threat of Splicing Factor Mutations to Myeloid Malignancies and Potential Therapeutic Modulations
por: Zhang, Fangliang, et al.
Publicado: (2022)

Alternative splicing of U2AF1 reveals a shared repression mechanism for duplicated exons
por: Kralovicova, Jana, et al.
Publicado: (2017)

RBM-5 modulates U2AF large subunit-dependent alternative splicing in C. elegans
por: Zhou, Chuanman, et al.
Publicado: (2018)

U2AF65-Dependent SF3B1 Function in SMN Alternative Splicing
por: Choi, Namjeong, et al.
Publicado: (2020)

A multimodal analysis of genomic and RNA splicing features in myeloid malignancies
por: Durmaz, Arda, et al.
Publicado: (2023)

A Pan-Cancer Analysis of Transcriptome Changes Associated with Somatic Mutations in U2AF1 Reveals Commonly Altered Splicing Events
por: Brooks, Angela N., et al.
Publicado: (2014)

U2AF(65) adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs
por: Jenkins, Jermaine L., et al.
Publicado: (2013)

The RNA binding protein FgRbp1 regulates specific pre-mRNA splicing via interacting with U2AF23 in Fusarium
por: Wang, Minhui, et al.
Publicado: (2021)

Alteration of the SETBP1 Gene and Splicing Pathway Genes SF3B1, U2AF1, and SRSF2 in Childhood Acute Myeloid Leukemia
por: Choi, Hyun-Woo, et al.
Publicado: (2015)

Representations of AF-algebras and of the group U (∞)
por: Strâtilâ, Şerban-Valentin, et al.
Publicado: (1975)

Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3′-splice site recognition
por: Zhang, Yun, et al.
Publicado: (2013)

Identification of GSX2 and AF10 as NUP98 partner genes in myeloid malignancies
por: Soler, G, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_4c89kn95g1360d687gagrim9id