β(2)-Integrin Adhesive Bond Tension under Shear Stress Modulates Cytosolic Calcium Flux and Neutrophil Inflammatory Response

On arrested neutrophils a focal adhesive cluster of ~200 high affinity (HA) β(2)-integrin bonds under tension is sufficient to trigger Ca(2+) flux that signals an increase in activation in direct proportion to increments in shear stress. We reasoned that a threshold tension acting on individual β(2)...

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Detalles Bibliográficos
Autores principales: Morikis, Vasilios Aris, Chen, Szu Jung, Madigan, Julianna, Jo, Myung Hyun, Werba, Lisette Caroline, Ha, Taekjip, Simon, Scott Irwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497066/
https://www.ncbi.nlm.nih.gov/pubmed/36139397
http://dx.doi.org/10.3390/cells11182822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497066/
https://www.ncbi.nlm.nih.gov/pubmed/36139397
http://dx.doi.org/10.3390/cells11182822

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