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β(2)-Integrin Adhesive Bond Tension under Shear Stress Modulates Cytosolic Calcium Flux and Neutrophil Inflammatory Response
On arrested neutrophils a focal adhesive cluster of ~200 high affinity (HA) β(2)-integrin bonds under tension is sufficient to trigger Ca(2+) flux that signals an increase in activation in direct proportion to increments in shear stress. We reasoned that a threshold tension acting on individual β(2)...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497066/ https://www.ncbi.nlm.nih.gov/pubmed/36139397 http://dx.doi.org/10.3390/cells11182822 |