A BET Protein Inhibitor Targeting Mononuclear Myeloid Cells Affects Specific Inflammatory Mediators and Pathways in Crohn’s Disease

Background: Myeloid cells are critical determinants of the sustained inflammation in Crohn’s Disease (CD). Targeting such cells may be an effective therapeutic approach for refractory CD patients. Bromodomain and extra-terminal domain protein inhibitors (iBET) are potent anti-inflammatory agents; ho...

Descripción completa

Detalles Bibliográficos
Autores principales: Elfiky, Ahmed M. I., Hageman, Ishtu L., Becker, Marte A. J., Verhoeff, Jan, Li Yim, Andrew Y. F., Joustra, Vincent W., Mulders, Lieven, Fung, Ivan, Rioja, Inmaculada, Prinjha, Rab K., Smithers, Nicholas N., Furze, Rebecca C., Mander, Palwinder K., Bell, Matthew J., Buskens, Christianne J., D’Haens, Geert R., Wildenberg, Manon E., de Jonge, Wouter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497176/
https://www.ncbi.nlm.nih.gov/pubmed/36139421
http://dx.doi.org/10.3390/cells11182846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497176/
https://www.ncbi.nlm.nih.gov/pubmed/36139421
http://dx.doi.org/10.3390/cells11182846

Ejemplares similares