Cargando…

A BET Protein Inhibitor Targeting Mononuclear Myeloid Cells Affects Specific Inflammatory Mediators and Pathways in Crohn’s Disease

Background: Myeloid cells are critical determinants of the sustained inflammation in Crohn’s Disease (CD). Targeting such cells may be an effective therapeutic approach for refractory CD patients. Bromodomain and extra-terminal domain protein inhibitors (iBET) are potent anti-inflammatory agents; ho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elfiky, Ahmed M. I., Hageman, Ishtu L., Becker, Marte A. J., Verhoeff, Jan, Li Yim, Andrew Y. F., Joustra, Vincent W., Mulders, Lieven, Fung, Ivan, Rioja, Inmaculada, Prinjha, Rab K., Smithers, Nicholas N., Furze, Rebecca C., Mander, Palwinder K., Bell, Matthew J., Buskens, Christianne J., D’Haens, Geert R., Wildenberg, Manon E., de Jonge, Wouter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497176/ https://www.ncbi.nlm.nih.gov/pubmed/36139421 http://dx.doi.org/10.3390/cells11182846

Ejemplares similares

BET Inhibition Improves NASH and Liver Fibrosis
por: Middleton, Sarah A., et al.
Publicado: (2018)

Peripheral Blood DNA Methylation Profiles Do Not Predict Endoscopic Post-Operative Recurrence in Crohn’s Disease Patients
por: Joustra, Vincent W., et al.
Publicado: (2022)

Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease
por: Elfiky, Ahmed M I, et al.
Publicado: (2021)

Long-term Temporal Stability of Peripheral Blood DNA Methylation Profiles in Patients With Inflammatory Bowel Disease
por: Joustra, Vincent, et al.
Publicado: (2022)

Systematic Review and Meta-analysis of Peripheral Blood DNA Methylation Studies in Inflammatory Bowel Disease
por: Joustra, Vincent, et al.
Publicado: (2022)

Bromodomain inhibitor I‐BET151 suppresses immune responses during fungal–immune interaction
por: Domínguez‐Andrés, Jorge, et al.
Publicado: (2019)

Inhibition of BET Proteins Reduces Right Ventricle Hypertrophy and Pulmonary Hypertension Resulting from Combined Hypoxia and Pulmonary Inflammation
por: Chabert, Clovis, et al.
Publicado: (2018)

High prevalence of ulcerative appendicitis in patients with ulcerative colitis
por: Heuthorst, Lianne, et al.
Publicado: (2021)

Natural History and Risk Stratification of Recurrent Crohn’s Disease After Ileocolonic Resection: A Multicenter Retrospective Cohort Study
por: Joustra, Vincent, et al.
Publicado: (2021)

Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells
por: Fu, Wenxian, et al.
Publicado: (2014)

Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis
por: Luque-Martin, Rosario, et al.
Publicado: (2019)

A distinct epigenetic profile distinguishes stenotic from non-inflamed fibroblasts in the ileal mucosa of Crohn’s disease patients
por: Li Yim, Andrew Y. F., et al.
Publicado: (2018)

The Future of Janus Kinase Inhibitors in Inflammatory Bowel Disease
por: De Vries, L.C.S., et al.
Publicado: (2017)

Muscle hypertrophy in hypoxia with inflammation is controlled by bromodomain and extra-terminal domain proteins
por: Chabert, Clovis, et al.
Publicado: (2017)

Intestinal fibrosis is associated with lack of response to Infliximab therapy in Crohn's disease
por: de Bruyn, Jessica R., et al.
Publicado: (2018)

Tyrosine Kinase 2 Signalling Drives Pathogenic T cells in Colitis
por: De Vries, Leonie C S, et al.
Publicado: (2020)

Wound healing of metastatic perineal Crohn’s disease using hyperbaric oxygen therapy: A case series
por: Lansdorp, Corine A, et al.
Publicado: (2020)

Epigenetic Signatures Discriminate Patients With Primary Sclerosing Cholangitis and Ulcerative Colitis From Patients With Ulcerative Colitis
por: de Krijger, Manon, et al.
Publicado: (2022)

Diagnostic accuracy of faecal calprotectin in patients with active perianal fistulas
por: Stevens, Toer W, et al.
Publicado: (2019)

Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice
por: Sullivan, Josefa M., et al.
Publicado: (2015)

Benefit of Risk-stratified Prophylactic Treatment on Clinical Outcome in Postoperative Crohn’s Disease
por: Joustra, Vincent, et al.
Publicado: (2022)

Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling
por: Heinemann, Anja, et al.
Publicado: (2015)

Inhibition of Osteoclastogenesis and Inflammatory Bone Resorption by Targeting BET Proteins and Epigenetic Regulation
por: Park-Min, Kyung-Hyun, et al.
Publicado: (2014)

N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells
por: Nord, Joshua A., et al.
Publicado: (2022)

Intestinal ultrasound detects an increased diameter and submucosal layer thickness in the appendix of patients with ulcerative colitis compared to healthy controls – a prospective cohort study
por: Reijntjes, Maud A., et al.
Publicado: (2022)

Increased Proportion of Colorectal Cancer in Patients With Ulcerative Colitis Undergoing Surgery in the Netherlands
por: Heuthorst, Lianne, et al.
Publicado: (2023)

Hyperbaric oxygen therapy for the treatment of perianal fistulas in 20 patients with Crohn’s disease
por: Lansdorp, Corine A., et al.
Publicado: (2020)

Hyperbaric oxygen therapy for the treatment of perianal fistulas in 20 patients with Crohn's disease: Results of the HOT‐TOPIC trial after 1‐year follow‐up
por: Lansdorp, Corine A., et al.
Publicado: (2022)

Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo
por: Falcinelli, Shane D., et al.
Publicado: (2022)

Hyperbaric oxygen therapy for the treatment of rectovaginal fistulas in patients with Crohn’s disease: results of the HOT-REVA pilot study
por: Lansdorp, C A, et al.
Publicado: (2021)

Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration
por: Mander, Palwinder, et al.
Publicado: (2005)

Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells
por: Quintela, Marcos, et al.
Publicado: (2023)

Fibrosis and MAGNIFI-CD Activity Index at Magnetic Resonance Imaging to Predict Treatment Outcome in Perianal Fistulizing Crohn’s Disease Patients
por: van Rijn, Kyra L, et al.
Publicado: (2021)

Chromatin targeting drugs in cancer and immunity
por: Prinjha, Rab, et al.
Publicado: (2013)

Short-term anti-TNF therapy with surgical closure versus anti-TNF therapy alone for Crohn's perianal fistulas (PISA-II): long-term outcomes of an international, multicentre patient preference, randomised controlled trial
por: Meima - van Praag, Elise M., et al.
Publicado: (2023)

Anatomical Variation in Mesenteric Macrophage Phenotypes in Crohn's Disease
por: van der Meer, Jonathan H.M., et al.
Publicado: (2020)

Drawing on disorder: How viruses use histone mimicry to their advantage
por: Tarakhovsky, Alexander, et al.
Publicado: (2018)

Bromodomain Inhibitors Modulate FcγR-Mediated Mononuclear Phagocyte Activation and Chemotaxis
por: Banham, Gemma D., et al.
Publicado: (2022)

Next-Generation Therapeutics for IBD
por: Löwenberg, Mark, et al.
Publicado: (2015)

BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models
por: Wyce, Anastasia, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vf378m4ngfd0nrdde2urgrd8tt