Viral Particle-Mediated SAMHD1 Depletion Sensitizes Refractory Glioblastoma to DNA-Damaging Therapeutics by Impairing Homologous Recombination

SIMPLE SUMMARY: Glioblastoma (GBM) is a lethal and common primary brain tumor that accounts for about 50% of all diagnosed malignant gliomas. Despite aggressive standard-of-care treatment of surgical resection followed by γ-irradiation (IR) and DNA alkylating agent temozolomide (TMZ), the average po...

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Detalles Bibliográficos
Autores principales: Daddacha, Waaqo, Monroe, Dominique, Carver, Kristen, Usoro, Edidiong R., Alptekin, Ahmet, Xu, Hongyan, Osuka, Satoru, Arbab, Ali S., Sakamuro, Daitoku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497202/
https://www.ncbi.nlm.nih.gov/pubmed/36139652
http://dx.doi.org/10.3390/cancers14184490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497202/
https://www.ncbi.nlm.nih.gov/pubmed/36139652
http://dx.doi.org/10.3390/cancers14184490

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