Hyperactive Akt1 Signaling Increases Tumor Progression and DNA Repair in Embryonal Rhabdomyosarcoma RD Line and Confers Susceptibility to Glycolysis and Mevalonate Pathway Inhibitors

In pediatric rhabdomyosarcoma (RMS), elevated Akt signaling is associated with increased malignancy. Here, we report that expression of a constitutively active, myristoylated form of Akt1 (myrAkt1) in human RMS RD cells led to hyperactivation of the mammalian target of rapamycin (mTOR)/70-kDa riboso...

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Detalles Bibliográficos
Autores principales: Codenotti, Silvia, Zizioli, Daniela, Mignani, Luca, Rezzola, Sara, Tabellini, Giovanna, Parolini, Silvia, Giacomini, Arianna, Asperti, Michela, Poli, Maura, Mandracchia, Delia, Vezzoli, Marika, Bernardi, Simona, Russo, Domenico, Mitola, Stefania, Monti, Eugenio, Triggiani, Luca, Tomasini, Davide, Gastaldello, Stefano, Cassandri, Matteo, Rota, Rossella, Marampon, Francesco, Fanzani, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497225/
https://www.ncbi.nlm.nih.gov/pubmed/36139434
http://dx.doi.org/10.3390/cells11182859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497225/
https://www.ncbi.nlm.nih.gov/pubmed/36139434
http://dx.doi.org/10.3390/cells11182859

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