mTORC1 Activity in Psoriatic Lesions Is Mediated by Aberrant Regulation through the Tuberous Sclerosis Complex

In the basal, proliferative layer of healthy skin, the mTOR complex 1 (mTORC1) is activated, thus regulating proliferation while preventing differentiation. When cells leave the proliferative, basal compartment, mTORC1 signaling is turned off, which allows differentiation. Under inflammatory conditi...

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Detalles Bibliográficos
Autores principales: Ferreri, Antonio, Lang, Victoria, Kaufmann, Roland, Buerger, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497233/
https://www.ncbi.nlm.nih.gov/pubmed/36139422
http://dx.doi.org/10.3390/cells11182847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497233/
https://www.ncbi.nlm.nih.gov/pubmed/36139422
http://dx.doi.org/10.3390/cells11182847

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