Cargando…

Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk

Commonly consumed foods and beverages can contain chemicals with reported carcinogenic activity in rodent models. Moreover, exposures to some of these substances have been associated with increased cancer risks in humans. Food-borne carcinogens span a range of chemical classes and can arise from nat...

Descripción completa

Detalles Bibliográficos
Autores principales: Kobets, Tetyana, Smith, Benjamin P. C., Williams, Gary M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497933/
https://www.ncbi.nlm.nih.gov/pubmed/36140952
http://dx.doi.org/10.3390/foods11182828
_version_ 1784794630878920704
author Kobets, Tetyana
Smith, Benjamin P. C.
Williams, Gary M.
author_facet Kobets, Tetyana
Smith, Benjamin P. C.
Williams, Gary M.
author_sort Kobets, Tetyana
collection PubMed
description Commonly consumed foods and beverages can contain chemicals with reported carcinogenic activity in rodent models. Moreover, exposures to some of these substances have been associated with increased cancer risks in humans. Food-borne carcinogens span a range of chemical classes and can arise from natural or anthropogenic sources, as well as form endogenously. Important considerations include the mechanism(s) of action (MoA), their relevance to human biology, and the level of exposure in diet. The MoAs of carcinogens have been classified as either DNA-reactive (genotoxic), involving covalent reaction with nuclear DNA, or epigenetic, involving molecular and cellular effects other than DNA reactivity. Carcinogens are generally present in food at low levels, resulting in low daily intakes, although there are some exceptions. Carcinogens of the DNA-reactive type produce effects at lower dosages than epigenetic carcinogens. Several food-related DNA-reactive carcinogens, including aflatoxins, aristolochic acid, benzene, benzo[a]pyrene and ethylene oxide, are recognized by the International Agency for Research on Cancer (IARC) as causes of human cancer. Of the epigenetic type, the only carcinogen considered to be associated with increased cancer in humans, although not from low-level food exposure, is dioxin (TCDD). Thus, DNA-reactive carcinogens in food represent a much greater risk than epigenetic carcinogens.
format Online
Article
Text
id pubmed-9497933
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94979332022-09-23 Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk Kobets, Tetyana Smith, Benjamin P. C. Williams, Gary M. Foods Review Commonly consumed foods and beverages can contain chemicals with reported carcinogenic activity in rodent models. Moreover, exposures to some of these substances have been associated with increased cancer risks in humans. Food-borne carcinogens span a range of chemical classes and can arise from natural or anthropogenic sources, as well as form endogenously. Important considerations include the mechanism(s) of action (MoA), their relevance to human biology, and the level of exposure in diet. The MoAs of carcinogens have been classified as either DNA-reactive (genotoxic), involving covalent reaction with nuclear DNA, or epigenetic, involving molecular and cellular effects other than DNA reactivity. Carcinogens are generally present in food at low levels, resulting in low daily intakes, although there are some exceptions. Carcinogens of the DNA-reactive type produce effects at lower dosages than epigenetic carcinogens. Several food-related DNA-reactive carcinogens, including aflatoxins, aristolochic acid, benzene, benzo[a]pyrene and ethylene oxide, are recognized by the International Agency for Research on Cancer (IARC) as causes of human cancer. Of the epigenetic type, the only carcinogen considered to be associated with increased cancer in humans, although not from low-level food exposure, is dioxin (TCDD). Thus, DNA-reactive carcinogens in food represent a much greater risk than epigenetic carcinogens. MDPI 2022-09-13 /pmc/articles/PMC9497933/ /pubmed/36140952 http://dx.doi.org/10.3390/foods11182828 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kobets, Tetyana
Smith, Benjamin P. C.
Williams, Gary M.
Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk
title Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk
title_full Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk
title_fullStr Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk
title_full_unstemmed Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk
title_short Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk
title_sort food-borne chemical carcinogens and the evidence for human cancer risk
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497933/
https://www.ncbi.nlm.nih.gov/pubmed/36140952
http://dx.doi.org/10.3390/foods11182828
work_keys_str_mv AT kobetstetyana foodbornechemicalcarcinogensandtheevidenceforhumancancerrisk
AT smithbenjaminpc foodbornechemicalcarcinogensandtheevidenceforhumancancerrisk
AT williamsgarym foodbornechemicalcarcinogensandtheevidenceforhumancancerrisk