SR Protein Kinases Regulate the Splicing of Cardiomyopathy-Relevant Genes via Phosphorylation of the RSRSP Stretch in RBM20

(1) Background: RNA binding motif 20 (RBM20) regulates mRNA splicing specifically in muscle tissues. Missense mutations in the arginine/serine (RS) domain of RBM20 lead to abnormal gene splicing and have been linked to severe dilated cardiomyopathy (DCM) in human patients and animal models. Interest...

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Detalles Bibliográficos
Autores principales: Sun, Mingming, Jin, Yutong, Zhang, Yanghai, Gregorich, Zachery R, Ren, Jun, Ge, Ying, Guo, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498672/
https://www.ncbi.nlm.nih.gov/pubmed/36140694
http://dx.doi.org/10.3390/genes13091526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498672/
https://www.ncbi.nlm.nih.gov/pubmed/36140694
http://dx.doi.org/10.3390/genes13091526

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