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SR Protein Kinases Regulate the Splicing of Cardiomyopathy-Relevant Genes via Phosphorylation of the RSRSP Stretch in RBM20

(1) Background: RNA binding motif 20 (RBM20) regulates mRNA splicing specifically in muscle tissues. Missense mutations in the arginine/serine (RS) domain of RBM20 lead to abnormal gene splicing and have been linked to severe dilated cardiomyopathy (DCM) in human patients and animal models. Interest...

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Detalles Bibliográficos
Autores principales:	Sun, Mingming, Jin, Yutong, Zhang, Yanghai, Gregorich, Zachery R, Ren, Jun, Ge, Ying, Guo, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498672/ https://www.ncbi.nlm.nih.gov/pubmed/36140694 http://dx.doi.org/10.3390/genes13091526

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