Loss of Serpina1 in Mice Leads to Altered Gene Expression in Inflammatory and Metabolic Pathways

The SERPINA1 gene encodes alpha1-antitrypsin (AAT), an acute phase glycoprotein and serine protease inhibitor that is mainly (80–90%) produced in the liver. Point mutations in the SERPINA1 gene can lead to the misfolding, intracellular accumulation, and deficiency of circulating AAT protein, increas...

Descripción completa

Detalles Bibliográficos
Autores principales: Meghadri, Sri Harsha, Martinez-Delgado, Beatriz, Ostermann, Lena, Gomez-Mariano, Gema, Perez-Luz, Sara, Tumpara, Srinu, Wrenger, Sabine, DeLuca, David S., Maus, Ulrich A., Welte, Tobias, Janciauskiene, Sabina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499171/
https://www.ncbi.nlm.nih.gov/pubmed/36142337
http://dx.doi.org/10.3390/ijms231810425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499171/
https://www.ncbi.nlm.nih.gov/pubmed/36142337
http://dx.doi.org/10.3390/ijms231810425

Ejemplares similares