Vaccine-linked chemotherapy with a low dose of benznidazole plus a bivalent recombinant protein vaccine prevents the development of cardiac fibrosis caused by Trypanosoma cruzi in chronically-infected BALB/c mice

BACKGROUND: Chagas disease (CD) is caused by Trypanosoma cruzi and affects 6–7 million people worldwide. Approximately 30% of chronic patients develop chronic chagasic cardiomyopathy (CCC) after decades. Benznidazole (BNZ), one of the first-line chemotherapy used for CD, induces toxicity and fails t...

Descripción completa

Detalles Bibliográficos
Autores principales: Dzul-Huchim, Victor Manuel, Ramirez-Sierra, Maria Jesus, Martinez-Vega, Pedro Pablo, Rosado-Vallado, Miguel Enrique, Arana-Argaez, Victor Ermilo, Ortega-Lopez, Jaime, Gusovsky, Fabian, Dumonteil, Eric, Cruz-Chan, Julio Vladimir, Hotez, Peter, Bottazzi, María Elena, Villanueva-Lizama, Liliana Estefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499242/
https://www.ncbi.nlm.nih.gov/pubmed/36095001
http://dx.doi.org/10.1371/journal.pntd.0010258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499242/
https://www.ncbi.nlm.nih.gov/pubmed/36095001
http://dx.doi.org/10.1371/journal.pntd.0010258

Ejemplares similares