Diverse Roles of the Exon Junction Complex Factors in the Cell Cycle, Cancer, and Neurodevelopmental Disorders-Potential for Therapeutic Targeting

The exon junction complex (EJC) plays a crucial role in regulating gene expression at the levels of alternative splicing, translation, mRNA localization, and nonsense-mediated decay (NMD). The EJC is comprised of three core proteins: RNA-binding motif 8A (RBM8A), Mago homolog (MAGOH), eukaryotic ini...

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Detalles Bibliográficos
Autores principales: Martin, Hannah, Rupkey, Julian, Asthana, Shravan, Yoon, Joy, Patel, Shray, Mott, Jennifer, Pei, Zifei, Mao, Yingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499366/
https://www.ncbi.nlm.nih.gov/pubmed/36142288
http://dx.doi.org/10.3390/ijms231810375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499366/
https://www.ncbi.nlm.nih.gov/pubmed/36142288
http://dx.doi.org/10.3390/ijms231810375

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