Unraveling the Role of the Tyrosine Tetrad from the Binding Site of the Epigenetic Writer MLL3 in the Catalytic Mechanism and Methylation Multiplicity

MLL3, also known as KMT2C, is a lysine mono-methyltransferase in charge of the writing of an epigenetic mark on lysine 4 from histone 3. The catalytic site of MLL3 is composed of four tyrosines, namely, Y44, Y69, Y128, and Y130. Tyrosine residues are highly conserved among lysine methyltransferases’...

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Detalles Bibliográficos
Autores principales: Blanco-Esperguez, Kevin, Tuñón, Iñaki, Kästner, Johannes, Mendizábal, Fernando, Miranda-Rojas, Sebastián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499395/
https://www.ncbi.nlm.nih.gov/pubmed/36142254
http://dx.doi.org/10.3390/ijms231810339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499395/
https://www.ncbi.nlm.nih.gov/pubmed/36142254
http://dx.doi.org/10.3390/ijms231810339

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