Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome

The human Mixed Lineage Leukemia-1 (MLL1) complex methylates histone H3K4 to promote transcription and is stimulated by monoubiquitination of histone H2B. Recent structures of the MLL1-WRAD core complex, which comprises the MLL1 methyltransferase, WDR5, RbBp5, Ash2L, and DPY-30, have revealed variab...

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Detalles Bibliográficos
Autores principales: Rahman, Sanim, Hoffmann, Niklas A., Worden, Evan J., Smith, Marissa L., Namitz, Kevin E. W., Knutson, Bruce A., Cosgrove, Michael S., Wolberger, Cynthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499523/
https://www.ncbi.nlm.nih.gov/pubmed/36095189
http://dx.doi.org/10.1073/pnas.2205691119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499523/
https://www.ncbi.nlm.nih.gov/pubmed/36095189
http://dx.doi.org/10.1073/pnas.2205691119

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