Most cancers carry a substantial deleterious load due to Hill-Robertson interference

Cancer genomes exhibit surprisingly weak signatures of negative selection (Martincorena et al., 2017; Weghorn, 2017). This may be because selective pressures are relaxed or because genome-wide linkage prevents deleterious mutations from being removed (Hill-Robertson interference; Hill and Robertson,...

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Detalles Bibliográficos
Autores principales: Tilk, Susanne, Tkachenko, Svyatoslav, Curtis, Christina, Petrov, Dmitri A, McFarland, Christopher D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499534/
https://www.ncbi.nlm.nih.gov/pubmed/36047771
http://dx.doi.org/10.7554/eLife.67790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499534/
https://www.ncbi.nlm.nih.gov/pubmed/36047771
http://dx.doi.org/10.7554/eLife.67790

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