A crosstalk between hepcidin and IRE/IRP pathways controls ferroportin expression and determines serum iron levels in mice

The iron hormone hepcidin is transcriptionally activated by iron or inflammation via distinct, partially overlapping pathways. We addressed how iron affects inflammatory hepcidin levels and the ensuing hypoferremic response. Dietary iron overload did not mitigate hepcidin induction in lipopolysaccha...

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Detalles Bibliográficos
Autores principales: Charlebois, Edouard, Fillebeen, Carine, Katsarou, Angeliki, Rabinovich, Aleksandr, Wisniewski, Kazimierz, Venkataramani, Vivek, Michalke, Bernhard, Velentza, Anastasia, Pantopoulos, Kostas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499557/
https://www.ncbi.nlm.nih.gov/pubmed/36066082
http://dx.doi.org/10.7554/eLife.81332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499557/
https://www.ncbi.nlm.nih.gov/pubmed/36066082
http://dx.doi.org/10.7554/eLife.81332

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