A scalable framework for the discovery of functional helicase substrates and helicase-driven regulatory switches

Helicases are ubiquitous motor enzymes that remodel nucleic acids (NA) and NA–protein complexes in key cellular processes. To explore the functional repertoire and specificity landscape of helicases, we devised a screening scheme—Helicase-SELEX (Systematic Evolution of Ligands by EXponential enrichm...

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Detalles Bibliográficos
Autores principales: Delaleau, Mildred, Eveno, Eric, Simon, Isabelle, Schwartz, Annie, Boudvillain, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499579/
https://www.ncbi.nlm.nih.gov/pubmed/36095194
http://dx.doi.org/10.1073/pnas.2209608119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499579/
https://www.ncbi.nlm.nih.gov/pubmed/36095194
http://dx.doi.org/10.1073/pnas.2209608119

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