Melatonin Inhibits hIAPP Oligomerization by Preventing β-Sheet and Hydrogen Bond Formation of the Amyloidogenic Region Revealed by Replica-Exchange Molecular Dynamics Simulation

The pathogenesis of type 2 diabetes (T2D) is highly related to the abnormal self-assembly of the human islet amyloid polypeptide (hIAPP) into amyloid aggregates. To inhibit hIAPP aggregation is considered a promising therapeutic strategy for T2D treatment. Melatonin (Mel) was reported to effectively...

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Detalles Bibliográficos
Autores principales: Wang, Gang, Zhu, Xinyi, Song, Xiaona, Zhang, Qingwen, Qian, Zhenyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499688/
https://www.ncbi.nlm.nih.gov/pubmed/36142176
http://dx.doi.org/10.3390/ijms231810264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499688/
https://www.ncbi.nlm.nih.gov/pubmed/36142176
http://dx.doi.org/10.3390/ijms231810264

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