Inhibition of GABA(A) receptors in intestinal stem cells prevents chemoradiotherapy-induced intestinal toxicity

Lethal intestinal tissue toxicity is a common side effect and a dose-limiting factor in chemoradiotherapy. Chemoradiotherapy can trigger DNA damage and induce P53-dependent apoptosis in LGR5(+) intestinal stem cells (ISCs). Gamma-aminobutyric acid (GABA) and its A receptors (GABA(A)R) are present in...

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Detalles Bibliográficos
Autores principales: Zhang, Cuiyu, Zhou, Yuping, Zheng, Junjie, Ning, Nannan, Liu, Haining, Jiang, Wenyang, Yu, Xin, Mu, Kun, Li, Yan, Guo, Wei, Hu, Huili, Li, Jingxin, Chen, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499828/
https://www.ncbi.nlm.nih.gov/pubmed/36125780
http://dx.doi.org/10.1084/jem.20220541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499828/
https://www.ncbi.nlm.nih.gov/pubmed/36125780
http://dx.doi.org/10.1084/jem.20220541

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