Genetic risk factors have a substantial impact on healthy life years

The impact of genetic variation on overall disease burden has not been comprehensively evaluated. We introduce an approach to estimate the effect of genetic risk factors on disability-adjusted life years (DALYs; ‘lost healthy life years’). We use genetic information from 735,748 individuals and cons...

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Autores principales: Jukarainen, Sakari, Kiiskinen, Tuomo, Kuitunen, Sara, Havulinna, Aki S., Karjalainen, Juha, Cordioli, Mattia, Rämö, Joel T., Mars, Nina, Samocha, Kaitlin E., Ollila, Hanna M., Pirinen, Matti, Ganna, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499866/
https://www.ncbi.nlm.nih.gov/pubmed/36097220
http://dx.doi.org/10.1038/s41591-022-01957-2
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author Jukarainen, Sakari
Kiiskinen, Tuomo
Kuitunen, Sara
Havulinna, Aki S.
Karjalainen, Juha
Cordioli, Mattia
Rämö, Joel T.
Mars, Nina
Samocha, Kaitlin E.
Ollila, Hanna M.
Pirinen, Matti
Ganna, Andrea
author_facet Jukarainen, Sakari
Kiiskinen, Tuomo
Kuitunen, Sara
Havulinna, Aki S.
Karjalainen, Juha
Cordioli, Mattia
Rämö, Joel T.
Mars, Nina
Samocha, Kaitlin E.
Ollila, Hanna M.
Pirinen, Matti
Ganna, Andrea
author_sort Jukarainen, Sakari
collection PubMed
description The impact of genetic variation on overall disease burden has not been comprehensively evaluated. We introduce an approach to estimate the effect of genetic risk factors on disability-adjusted life years (DALYs; ‘lost healthy life years’). We use genetic information from 735,748 individuals and consider 80 diseases. Rare variants had the highest effect on DALYs at the individual level. Among common variants, rs3798220 (LPA) had the strongest individual-level effect, with 1.18 DALYs from carrying 1 versus 0 copies. Being in the top 10% versus the bottom 90% of a polygenic score for multisite chronic pain had an effect of 3.63 DALYs. Some common variants had a population-level effect comparable to modifiable risk factors such as high sodium intake and low physical activity. Attributable DALYs vary between males and females for some genetic exposures. Genetic risk factors can explain a sizable number of healthy life years lost both at the individual and population level.
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spelling pubmed-94998662022-09-24 Genetic risk factors have a substantial impact on healthy life years Jukarainen, Sakari Kiiskinen, Tuomo Kuitunen, Sara Havulinna, Aki S. Karjalainen, Juha Cordioli, Mattia Rämö, Joel T. Mars, Nina Samocha, Kaitlin E. Ollila, Hanna M. Pirinen, Matti Ganna, Andrea Nat Med Article The impact of genetic variation on overall disease burden has not been comprehensively evaluated. We introduce an approach to estimate the effect of genetic risk factors on disability-adjusted life years (DALYs; ‘lost healthy life years’). We use genetic information from 735,748 individuals and consider 80 diseases. Rare variants had the highest effect on DALYs at the individual level. Among common variants, rs3798220 (LPA) had the strongest individual-level effect, with 1.18 DALYs from carrying 1 versus 0 copies. Being in the top 10% versus the bottom 90% of a polygenic score for multisite chronic pain had an effect of 3.63 DALYs. Some common variants had a population-level effect comparable to modifiable risk factors such as high sodium intake and low physical activity. Attributable DALYs vary between males and females for some genetic exposures. Genetic risk factors can explain a sizable number of healthy life years lost both at the individual and population level. Nature Publishing Group US 2022-09-12 2022 /pmc/articles/PMC9499866/ /pubmed/36097220 http://dx.doi.org/10.1038/s41591-022-01957-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Jukarainen, Sakari
Kiiskinen, Tuomo
Kuitunen, Sara
Havulinna, Aki S.
Karjalainen, Juha
Cordioli, Mattia
Rämö, Joel T.
Mars, Nina
Samocha, Kaitlin E.
Ollila, Hanna M.
Pirinen, Matti
Ganna, Andrea
Genetic risk factors have a substantial impact on healthy life years
title Genetic risk factors have a substantial impact on healthy life years
title_full Genetic risk factors have a substantial impact on healthy life years
title_fullStr Genetic risk factors have a substantial impact on healthy life years
title_full_unstemmed Genetic risk factors have a substantial impact on healthy life years
title_short Genetic risk factors have a substantial impact on healthy life years
title_sort genetic risk factors have a substantial impact on healthy life years
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499866/
https://www.ncbi.nlm.nih.gov/pubmed/36097220
http://dx.doi.org/10.1038/s41591-022-01957-2
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