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A new system for multiplexed mosaic analysis of gene function in the mouse

In a recent issue of Cell, Liu et al. present an innovative mouse model system in which Cre/lox stochastically turns on transgenic expression of one out of up to 100 sgRNAs in somatic cells, creating genetic mosaicism that enables the multiplexed assessment of gene function in vivo.

Detalles Bibliográficos
Autores principales: Cai, Hongchen, Winslow, Monte M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499980/
https://www.ncbi.nlm.nih.gov/pubmed/36160047
http://dx.doi.org/10.1016/j.crmeth.2022.100295