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A new system for multiplexed mosaic analysis of gene function in the mouse
In a recent issue of Cell, Liu et al. present an innovative mouse model system in which Cre/lox stochastically turns on transgenic expression of one out of up to 100 sgRNAs in somatic cells, creating genetic mosaicism that enables the multiplexed assessment of gene function in vivo.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499980/ https://www.ncbi.nlm.nih.gov/pubmed/36160047 http://dx.doi.org/10.1016/j.crmeth.2022.100295 |
| _version_ | 1784795115887263744 |
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| author | Cai, Hongchen Winslow, Monte M. |
| author_facet | Cai, Hongchen Winslow, Monte M. |
| author_sort | Cai, Hongchen |
| collection | PubMed |
| description | In a recent issue of Cell, Liu et al. present an innovative mouse model system in which Cre/lox stochastically turns on transgenic expression of one out of up to 100 sgRNAs in somatic cells, creating genetic mosaicism that enables the multiplexed assessment of gene function in vivo. |
| format | Online Article Text |
| id | pubmed-9499980 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-94999802022-09-24 A new system for multiplexed mosaic analysis of gene function in the mouse Cai, Hongchen Winslow, Monte M. Cell Rep Methods Spotlight In a recent issue of Cell, Liu et al. present an innovative mouse model system in which Cre/lox stochastically turns on transgenic expression of one out of up to 100 sgRNAs in somatic cells, creating genetic mosaicism that enables the multiplexed assessment of gene function in vivo. Elsevier 2022-09-19 /pmc/articles/PMC9499980/ /pubmed/36160047 http://dx.doi.org/10.1016/j.crmeth.2022.100295 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Spotlight Cai, Hongchen Winslow, Monte M. A new system for multiplexed mosaic analysis of gene function in the mouse |
| title | A new system for multiplexed mosaic analysis of gene function in the mouse |
| title_full | A new system for multiplexed mosaic analysis of gene function in the mouse |
| title_fullStr | A new system for multiplexed mosaic analysis of gene function in the mouse |
| title_full_unstemmed | A new system for multiplexed mosaic analysis of gene function in the mouse |
| title_short | A new system for multiplexed mosaic analysis of gene function in the mouse |
| title_sort | new system for multiplexed mosaic analysis of gene function in the mouse |
| topic | Spotlight |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499980/ https://www.ncbi.nlm.nih.gov/pubmed/36160047 http://dx.doi.org/10.1016/j.crmeth.2022.100295 |
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