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A new system for multiplexed mosaic analysis of gene function in the mouse
In a recent issue of Cell, Liu et al. present an innovative mouse model system in which Cre/lox stochastically turns on transgenic expression of one out of up to 100 sgRNAs in somatic cells, creating genetic mosaicism that enables the multiplexed assessment of gene function in vivo.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499980/ https://www.ncbi.nlm.nih.gov/pubmed/36160047 http://dx.doi.org/10.1016/j.crmeth.2022.100295 |