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Tau(LUM), an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy
Tau protein aggregates are a defining neuropathological feature of “tauopathies,” a group of neurodegenerative disorders that include Alzheimer’s disease. In the current study, we develop a Drosophila split-luciferase-based sensor of tau-tau interaction. This model, which we term “tau(LUM),” allows...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500001/ https://www.ncbi.nlm.nih.gov/pubmed/36160048 http://dx.doi.org/10.1016/j.crmeth.2022.100292 |