Tau(LUM), an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy

Tau protein aggregates are a defining neuropathological feature of “tauopathies,” a group of neurodegenerative disorders that include Alzheimer’s disease. In the current study, we develop a Drosophila split-luciferase-based sensor of tau-tau interaction. This model, which we term “tau(LUM),” allows...

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Detalles Bibliográficos
Autores principales: Levy, Simon A., Zuniga, Gabrielle, Gonzalez, Elias M., Butler, David, Temple, Sally, Frost, Bess
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500001/
https://www.ncbi.nlm.nih.gov/pubmed/36160048
http://dx.doi.org/10.1016/j.crmeth.2022.100292

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