Hereditary E200K mutation within the prion protein gene alters human iPSC derived cardiomyocyte function

Cardiomyopathy is a co-morbidity of some prion diseases including genetic disease caused by mutations within the PrP gene (PRNP). Although the cellular prion protein (PrP) has been shown to protect against cardiotoxicity caused by oxidative stress, it is unclear if the cardiomyopathy is directly lin...

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Detalles Bibliográficos
Autores principales: Wood, Aleksandar R., Foliaki, Simote T., Groveman, Bradley R., Walters, Ryan O., Williams, Katie, Yuan, Jue, Zou, Wen-Quan, Haigh, Cathryn L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500067/
https://www.ncbi.nlm.nih.gov/pubmed/36138047
http://dx.doi.org/10.1038/s41598-022-19631-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500067/
https://www.ncbi.nlm.nih.gov/pubmed/36138047
http://dx.doi.org/10.1038/s41598-022-19631-5

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