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Hereditary E200K mutation within the prion protein gene alters human iPSC derived cardiomyocyte function
Cardiomyopathy is a co-morbidity of some prion diseases including genetic disease caused by mutations within the PrP gene (PRNP). Although the cellular prion protein (PrP) has been shown to protect against cardiotoxicity caused by oxidative stress, it is unclear if the cardiomyopathy is directly lin...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500067/ https://www.ncbi.nlm.nih.gov/pubmed/36138047 http://dx.doi.org/10.1038/s41598-022-19631-5 |