A report on the potential of Rac1/pSTAT3 protein levels in T lymphocytes to assess the pharmacodynamic effect of thiopurine therapy in Inflammatory Bowel Disease patients

The thiopurine derivatives azathioprine (AZA), mercaptopurine (MP) and tioguanine (TG) remain standard treatment of inflammatory bowel disease (IBD). The immune suppressive effect of thiopurines is primarily based on blocking the Ras-related C3 botulinum toxin substrate 1 (Rac1) causing apoptosis of...

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Detalles Bibliográficos
Autores principales: Deben, Debbie S., Creemers, Rob H., van Adrichem, Arjan J., Drent, Roosmarie, Merry, Audrey H. H., Leers, Mathie P. G., van Bodegraven, Adriaan A., Wong, Dennis R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500076/
https://www.ncbi.nlm.nih.gov/pubmed/36138194
http://dx.doi.org/10.1038/s41598-022-20197-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500076/
https://www.ncbi.nlm.nih.gov/pubmed/36138194
http://dx.doi.org/10.1038/s41598-022-20197-5

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