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RNAa-mediated epigenetic attenuation of the cell senescence via locus specific induction of endogenous SIRT1
SIRT1, a known regulator of cellular senescence, is a therapeutic target for age related disorders and its upregulation is a strategy to improve the cell therapeutic potentials of human mesenchymal stem cell (MSCs). Knockdown of natural antisense transcripts via small activating RNAs (RNAa) is an em...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500079/ https://www.ncbi.nlm.nih.gov/pubmed/36138054 http://dx.doi.org/10.1038/s41598-022-17972-9 |