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RNAa-mediated epigenetic attenuation of the cell senescence via locus specific induction of endogenous SIRT1

SIRT1, a known regulator of cellular senescence, is a therapeutic target for age related disorders and its upregulation is a strategy to improve the cell therapeutic potentials of human mesenchymal stem cell (MSCs). Knockdown of natural antisense transcripts via small activating RNAs (RNAa) is an em...

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Detalles Bibliográficos
Autores principales:	Mokhberian, Neda, Sharifi, Kazem, Soleymaninejadian, Ehsan, Eftekhary, Mohamad, Hashemi, Seyed Mahmoud, Farhadi, Shohreh, Miwa, Satomi, Ghanbarian, Hossein
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500079/ https://www.ncbi.nlm.nih.gov/pubmed/36138054 http://dx.doi.org/10.1038/s41598-022-17972-9

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