Massive annotation of bacterial l-asparaginases reveals their puzzling distribution and frequent gene transfer events

l-Asparaginases, which convert l-asparagine to l-aspartate and ammonia, come in five types, AI-AV. Some bacterial type AII enzymes are a key element in the treatment of acute lymphoblastic leukemia in children, but new l-asparaginases with better therapeutic properties are urgently needed. Here, we...

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Detalles Bibliográficos
Autores principales: Zielezinski, Andrzej, Loch, Joanna I., Karlowski, Wojciech M., Jaskolski, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500103/
https://www.ncbi.nlm.nih.gov/pubmed/36138049
http://dx.doi.org/10.1038/s41598-022-19689-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500103/
https://www.ncbi.nlm.nih.gov/pubmed/36138049
http://dx.doi.org/10.1038/s41598-022-19689-1

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