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Massive annotation of bacterial l-asparaginases reveals their puzzling distribution and frequent gene transfer events
l-Asparaginases, which convert l-asparagine to l-aspartate and ammonia, come in five types, AI-AV. Some bacterial type AII enzymes are a key element in the treatment of acute lymphoblastic leukemia in children, but new l-asparaginases with better therapeutic properties are urgently needed. Here, we...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500103/ https://www.ncbi.nlm.nih.gov/pubmed/36138049 http://dx.doi.org/10.1038/s41598-022-19689-1 |