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Transcriptional regulation of INK4/ARF locus by cis and trans mechanisms

9p21 locus is one of the most reproducible regions in genome-wide association studies (GWAS). The region harbors CDKN2A/B genes that code for p16(INK4a), p15(INK4b), and p14(ARF) proteins, and it also harbors a long gene desert adjacent to these genes. The polymorphisms that are associated with seve...

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Detalles Bibliográficos
Autores principales: Farooq, Umer, Notani, Dimple
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500187/
https://www.ncbi.nlm.nih.gov/pubmed/36158211
http://dx.doi.org/10.3389/fcell.2022.948351