Homozygous knockout of eEF2K alleviates cognitive deficits in APP/PS1 Alzheimer’s disease model mice independent of brain amyloid β pathology

Maintenance of memory and synaptic plasticity depends on de novo protein synthesis, and accumulating evidence implicates a role of dysregulated mRNA translation in cognitive impairments associated with Alzheimer’s disease (AD). Accumulating evidence demonstrates hyper-phosphorylation of translation...

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Detalles Bibliográficos
Autores principales: Kasica, Nicole P., Zhou, Xueyan, Jester, Hannah M., Holland, Caroline E., Ryazanov, Alexey G., Forshaw, Tom E., Furdui, Cristina M., Ma, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500344/
https://www.ncbi.nlm.nih.gov/pubmed/36158543
http://dx.doi.org/10.3389/fnagi.2022.959326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500344/
https://www.ncbi.nlm.nih.gov/pubmed/36158543
http://dx.doi.org/10.3389/fnagi.2022.959326

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