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Homozygous knockout of eEF2K alleviates cognitive deficits in APP/PS1 Alzheimer’s disease model mice independent of brain amyloid β pathology
Maintenance of memory and synaptic plasticity depends on de novo protein synthesis, and accumulating evidence implicates a role of dysregulated mRNA translation in cognitive impairments associated with Alzheimer’s disease (AD). Accumulating evidence demonstrates hyper-phosphorylation of translation...
Autores principales: | Kasica, Nicole P., Zhou, Xueyan, Jester, Hannah M., Holland, Caroline E., Ryazanov, Alexey G., Forshaw, Tom E., Furdui, Cristina M., Ma, Tao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500344/ https://www.ncbi.nlm.nih.gov/pubmed/36158543 http://dx.doi.org/10.3389/fnagi.2022.959326 |
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