Heparanase in cancer progression: Structure, substrate recognition and therapeutic potential

Heparanase, a member of the carbohydrate-active enzyme (CAZy) GH79 family, is an endo-β-glucuronidase capable of degrading the carbohydrate moiety of heparan sulphate proteoglycans, thus modulating and facilitating remodeling of the extracellular matrix. Heparanase activity is strongly associated wi...

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Detalles Bibliográficos
Autores principales: Yuan, Fengyan, Yang, Yiyuan, Zhou, Huiqin, Quan, Jing, Liu, Chongyang, Wang, Yi, Zhang, Yujing, Yu, Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500389/
https://www.ncbi.nlm.nih.gov/pubmed/36157032
http://dx.doi.org/10.3389/fchem.2022.926353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500389/
https://www.ncbi.nlm.nih.gov/pubmed/36157032
http://dx.doi.org/10.3389/fchem.2022.926353

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