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CARD8 makes coxsackievirus more “heartbreaking”

In this issue of JEM, Nadkarni et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20212117) identify CARD8 as an innate sensor triggered by coxsackievirus B3 proteases to drive pyroptosis of aortic endothelial cells and cardiac myocytes, fueling viral replication and heart inflammation.

Detalles Bibliográficos
Autores principales: Wang, Qiankun, Shan, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500452/
https://www.ncbi.nlm.nih.gov/pubmed/36129454
http://dx.doi.org/10.1084/jem.20221240