CARD8 makes coxsackievirus more “heartbreaking”

In this issue of JEM, Nadkarni et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20212117) identify CARD8 as an innate sensor triggered by coxsackievirus B3 proteases to drive pyroptosis of aortic endothelial cells and cardiac myocytes, fueling viral replication and heart inflammation.

Detalles Bibliográficos
Autores principales: Wang, Qiankun, Shan, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500452/
https://www.ncbi.nlm.nih.gov/pubmed/36129454
http://dx.doi.org/10.1084/jem.20221240
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author Wang, Qiankun
Shan, Liang
author_facet Wang, Qiankun
Shan, Liang
author_sort Wang, Qiankun
collection PubMed
description In this issue of JEM, Nadkarni et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20212117) identify CARD8 as an innate sensor triggered by coxsackievirus B3 proteases to drive pyroptosis of aortic endothelial cells and cardiac myocytes, fueling viral replication and heart inflammation.
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spelling pubmed-95004522023-03-21 CARD8 makes coxsackievirus more “heartbreaking” Wang, Qiankun Shan, Liang J Exp Med Insights In this issue of JEM, Nadkarni et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20212117) identify CARD8 as an innate sensor triggered by coxsackievirus B3 proteases to drive pyroptosis of aortic endothelial cells and cardiac myocytes, fueling viral replication and heart inflammation. Rockefeller University Press 2022-09-21 /pmc/articles/PMC9500452/ /pubmed/36129454 http://dx.doi.org/10.1084/jem.20221240 Text en © 2022 Wang and Shan https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Wang, Qiankun
Shan, Liang
CARD8 makes coxsackievirus more “heartbreaking”
title CARD8 makes coxsackievirus more “heartbreaking”
title_full CARD8 makes coxsackievirus more “heartbreaking”
title_fullStr CARD8 makes coxsackievirus more “heartbreaking”
title_full_unstemmed CARD8 makes coxsackievirus more “heartbreaking”
title_short CARD8 makes coxsackievirus more “heartbreaking”
title_sort card8 makes coxsackievirus more “heartbreaking”
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500452/
https://www.ncbi.nlm.nih.gov/pubmed/36129454
http://dx.doi.org/10.1084/jem.20221240
work_keys_str_mv AT wangqiankun card8makescoxsackievirusmoreheartbreaking
AT shanliang card8makescoxsackievirusmoreheartbreaking

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