Optimization of the Pharmacokinetic Profile of [(99m)Tc]Tc-N(4)-Bombesin Derivatives by Modification of the Pharmacophoric Gln-Trp Sequence

Current radiolabeled gastrin-releasing peptide receptor (GRPR) ligands usually suffer from high accumulation in GRPR-positive organs (pancreas, stomach), limiting tumor-to-background contrast in the abdomen. In novel N(4)-bombesin derivatives this was addressed by substitutions at the Gln(7)-Trp(8)...

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Detalles Bibliográficos
Autores principales: Günther, Thomas, Konrad, Matthias, Stopper, León, Kunert, Jan-Philip, Fischer, Sebastian, Beck, Roswitha, Casini, Angela, Wester, Hans-Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500665/
https://www.ncbi.nlm.nih.gov/pubmed/36145354
http://dx.doi.org/10.3390/ph15091133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500665/
https://www.ncbi.nlm.nih.gov/pubmed/36145354
http://dx.doi.org/10.3390/ph15091133

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