Albumin-Mediated Size Exclusion Chromatography: The Apparent Molecular Weight of PSMA Radioligands as Novel Parameter to Estimate Their Blood Clearance Kinetics

A meticulously adjusted pharmacokinetic profile and especially fine-tuned blood clearance kinetics are key characteristics of therapeutic radiopharmaceuticals. We, therefore, aimed to develop a method that allowed the estimation of blood clearance kinetics in vitro. For this purpose, (177)Lu-labeled...

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Detalles Bibliográficos
Autores principales: Kunert, Jan-Philip, Fischer, Sebastian, Wurzer, Alexander, Wester, Hans-Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500755/
https://www.ncbi.nlm.nih.gov/pubmed/36145382
http://dx.doi.org/10.3390/ph15091161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500755/
https://www.ncbi.nlm.nih.gov/pubmed/36145382
http://dx.doi.org/10.3390/ph15091161

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