Novel 4-Azapregnene Derivatives as Potential Anticancer Agents: Synthesis, Antiproliferative Activity and Molecular Docking Studies

A series of novel 21E-arylidene-4-azapregn-5-ene steroids has been successfully designed, synthesized and structurally characterized, and their antiproliferative activity was evaluated in four different cell lines. Within this group, the 21E-(pyridin-3-yl)methylidene derivative exhibited significant...

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Detalles Bibliográficos
Autores principales: Brito, Vanessa, Santos, Adriana Oliveira, Alves, Gilberto, Almeida, Paulo, Silvestre, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501232/
https://www.ncbi.nlm.nih.gov/pubmed/36144856
http://dx.doi.org/10.3390/molecules27186126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501232/
https://www.ncbi.nlm.nih.gov/pubmed/36144856
http://dx.doi.org/10.3390/molecules27186126

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