Cargando…

Novel 4-Azapregnene Derivatives as Potential Anticancer Agents: Synthesis, Antiproliferative Activity and Molecular Docking Studies

A series of novel 21E-arylidene-4-azapregn-5-ene steroids has been successfully designed, synthesized and structurally characterized, and their antiproliferative activity was evaluated in four different cell lines. Within this group, the 21E-(pyridin-3-yl)methylidene derivative exhibited significant...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brito, Vanessa, Santos, Adriana Oliveira, Alves, Gilberto, Almeida, Paulo, Silvestre, Samuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501232/ https://www.ncbi.nlm.nih.gov/pubmed/36144856 http://dx.doi.org/10.3390/molecules27186126

Ejemplares similares

New Estrone Oxime Derivatives: Synthesis, Cytotoxic Evaluation and Docking Studies
por: Canário, Catarina, et al.
Publicado: (2021)

Synthesis, In Vitro Biological Evaluation of Antiproliferative and Neuroprotective Effects and In Silico Studies of Novel 16E-Arylidene-5α,6α-epoxyepiandrosterone Derivatives
por: Brito, Vanessa, et al.
Publicado: (2023)

Highlights on Steroidal Arylidene Derivatives as a Source of Pharmacologically Active Compounds: A Review
por: Brito, Vanessa, et al.
Publicado: (2021)

Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents
por: Krzywik, Julia, et al.
Publicado: (2020)

Design, synthesis and antiproliferative screening of newly synthesized acrylate derivatives as potential anticancer agents
por: Alshaya, Dalal Sulaiman, et al.
Publicado: (2023)

Design, synthesis, in silico toxicity prediction, molecular docking, and evaluation of novel pyrazole derivatives as potential antiproliferative agents
por: Ravula, Parameshwar, et al.
Publicado: (2016)

Molecular Docking Compounds of Cinnamaldehyde Derivatives as Anticancer Agents
por: Warsito, Warsito, et al.
Publicado: (2021)

Novel Sulfonamide–Triazine Hybrid Derivatives: Docking, Synthesis, and Biological Evaluation as Anticancer Agents
por: Alelaimat, Mahmoud A., et al.
Publicado: (2023)

An Insight into Symmetrical Cyanine Dyes as Promising Selective Antiproliferative Agents in Caco-2 Colorectal Cancer Cells
por: Serrano, João L., et al.
Publicado: (2022)

Molecular docking, synthesis and biological significance of pyrimidine analogues as prospective antimicrobial and antiproliferative agents
por: Kumar, Sanjiv, et al.
Publicado: (2019)

Encapsulated polycaprolactone with triazole derivatives and selenium nanoparticles as promising antiproliferative and anticancer agents
por: Abdelhamid, Ahmed E., et al.
Publicado: (2023)

Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance
por: Ciavatta, Maria Letizia, et al.
Publicado: (2016)

Synthesis of Structurally Related Coumarin Derivatives as Antiproliferative Agents
por: Bruna-Haupt, Ezequiel F., et al.
Publicado: (2023)

Design, efficient synthesis and molecular docking of some novel thiazolyl-pyrazole derivatives as anticancer agents
por: Sayed, Abdelwahed R., et al.
Publicado: (2019)

Novel Pyrimidine Derivatives as Potential Anticancer Agents: Synthesis, Biological Evaluation and Molecular Docking Study
por: Tylińska, Beata, et al.
Publicado: (2021)

Design, synthesis, molecular docking and biological evaluation of new carbazole derivatives as anticancer, and antioxidant agents
por: Çapan, İrfan, et al.
Publicado: (2023)

Docking, Synthesis and Antiproliferative Activity of N-Acylhydrazone Derivatives Designed as Combretastatin A4 Analogues
por: do Amaral, Daniel Nascimento, et al.
Publicado: (2014)

Synthesis and Biological Evaluation of Apigenin Derivatives as Antibacterial and Antiproliferative Agents
por: Liu, Rui, et al.
Publicado: (2013)

Synthesis and in Vitro Screening of Phenylbipyridinylpyrazole Derivatives as Potential Antiproliferative Agents
por: Al-Sanea, Mohammad M., et al.
Publicado: (2015)

Synthesis and Biological Evaluation of Amino Chalcone Derivatives as Antiproliferative Agents
por: Lu, Chao-Fan, et al.
Publicado: (2020)

Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation
por: Ashraf, Zaman, et al.
Publicado: (2019)

Synthesis, Evaluation, and Mechanism Study of New Tepotinib Derivatives as Antiproliferative Agents
por: Zhang, Niu-niu, et al.
Publicado: (2019)

Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies
por: Ammazzalorso, Alessandra, et al.
Publicado: (2020)

Synthesis, characterization, molecular docking, antimalarial, and antiproliferative activities of benzyloxy-4-oxopyridin benzoate derivatives
por: Mohebi, Marjan, et al.
Publicado: (2022)

Synthesis, Biological Evaluation, and Molecular Docking of Novel Azolylhydrazonothiazoles as Potential Anticancer Agents
por: Al-Humaidi, Jehan Y., et al.
Publicado: (2023)

Synthesis, Biological Activity, ADME and Molecular Docking Studies of Novel Ursolic Acid Derivatives as Potent Anticancer Agents
por: Michalak, Olga, et al.
Publicado: (2023)

Synthesis and Antiproliferative Effect of Halogenated Coumarin Derivatives
por: Dettori, Tinuccia, et al.
Publicado: (2022)

Synthesis, DNA Binding, and Antiproliferative Activity of Novel Acridine-Thiosemicarbazone Derivatives
por: de Almeida, Sinara Mônica Vitalino, et al.
Publicado: (2015)

Novel Acrylate-Based Derivatives: Design, Synthesis, Antiproliferative Screening, and Docking Study as Potential Combretastatin Analogues
por: Fayad, Eman, et al.
Publicado: (2023)

Synthesis, biological evaluation and docking studies of 1,2,4-oxadiazole linked 5-fluorouracil derivatives as anticancer agents
por: Bommera, Ravi Kumar, et al.
Publicado: (2021)

Synthesis, Characterization and Activity Evaluation of Matrinic Acid Derivatives as Potential Antiproliferative Agents
por: Chao, Fan, et al.
Publicado: (2013)

Synthesis, Molecular Docking and Biological Evaluation of Glycyrrhizin Analogs as Anticancer Agents Targeting EGFR
por: Yang, Yong-An, et al.
Publicado: (2014)

Synthesis, and docking studies of novel heterocycles incorporating the indazolylthiazole moiety as antimicrobial and anticancer agents
por: Dawoud, Nadia T. A., et al.
Publicado: (2022)

Mechanochemical Synthesis and Molecular Docking Studies of New Azines Bearing Indole as Anticancer Agents
por: Ibrahim, Mohamed S., et al.
Publicado: (2023)

Synthesis and Evaluation of Pyrimidine Steroids as Antiproliferative Agents
por: Cortés-Percino, Alejandra, et al.
Publicado: (2019)

Cytotoxic Evaluation, Molecular Docking, and 2D-QSAR Studies of Dihydropyrimidinone Derivatives as Potential Anticancer Agents
por: Altaf, Reem, et al.
Publicado: (2022)

Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives
por: Majcher, Urszula, et al.
Publicado: (2018)

Synthesis, Molecular Docking and Anticancer Activity of Diflunisal Derivatives as Cyclooxygenase Enzyme Inhibitors
por: Coşkun, Göknil Pelin, et al.
Publicado: (2018)

Tropinone-Derived Alkaloids as Potent Anticancer Agents: Synthesis, Tyrosinase Inhibition, Mechanism of Action, DFT Calculation, and Molecular Docking Studies
por: Piechowska, Katarzyna, et al.
Publicado: (2020)

Design, Synthesis, Molecular Docking Study and Biological Evaluation of Novel γ-Carboline Derivatives of Latrepirdine (Dimebon) as Potent Anticancer Agents
por: Voggu, Ramakrishna, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_iro9cf9ok01a8eei8gqu5oeepn