Total Synthesis of the Four Stereoisomers of Cyclo(l-Trp-l-Arg) Raises Uncertainty of the Structures of the Natural Products and Invalidates Their Promising Antimicrobial Activities

New therapeutic options to combat the growing incidence of antimicrobial resistance are urgently needed. A 2015 publication reported the isolation and biological evaluation of two diketopiperazine natural products, cyclo(l-Trp-l-Arg) (CDP 2) and cyclo(d-Trp-d-Arg) (CDP 3), from an Achromobacter sp....

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Dan, Park, Daniel J., Cadelis, Melissa M., Douafer, Hana, Bourguet-Kondracki, Marie Lise, Brunel, Jean Michel, Copp, Brent R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501421/
https://www.ncbi.nlm.nih.gov/pubmed/36144649
http://dx.doi.org/10.3390/molecules27185913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501421/
https://www.ncbi.nlm.nih.gov/pubmed/36144649
http://dx.doi.org/10.3390/molecules27185913

Ejemplares similares