Unveiling the Essential Role of Arkadia’s Non-RING Elements in the Ubiquitination Process

Arkadia is a positive regulator of the TGFβ-SMAD2/3 pathway, acting through its C-terminal RING-H2 domain and targeting for degradation of its negative regulators. Here we explore the role of regions outside the RING domain (non-RING elements) of Arkadia on the E2-E3 interaction. The contribution of...

Descripción completa

Detalles Bibliográficos
Autores principales: Birkou, Maria, Delegkou, Georgia N., Marousis, Konstantinos D., Fragkaki, Nefeli, Toro, Tamara, Episkopou, Vasso, Spyroulias, Georgios A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501438/
https://www.ncbi.nlm.nih.gov/pubmed/36142504
http://dx.doi.org/10.3390/ijms231810585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501438/
https://www.ncbi.nlm.nih.gov/pubmed/36142504
http://dx.doi.org/10.3390/ijms231810585

Ejemplares similares