Cargando…
Fragment-Based and Structural Investigation for Discovery of JNK3 Inhibitors
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are related to cell proliferation, gene expression, and cell death. JNK isoform 3 (JNK3) is an important therapeutic target in varieties of pathological conditions including cancers and neuronal...
Autores principales: | Duong, Men Thi Hoai, Ahn, Hee-Chul |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501523/ https://www.ncbi.nlm.nih.gov/pubmed/36145648 http://dx.doi.org/10.3390/pharmaceutics14091900 |
Ejemplares similares
-
C-Jun N-terminal kinase inhibitors: Structural insight into kinase-inhibitor complexes
por: Duong, Men Thi Hoai, et al.
Publicado: (2020) -
Structural Comparison of hMDH2 Complexed with Natural Substrates and Cofactors: The Importance of Phosphate Binding for Active Conformation and Catalysis
por: Eo, Yumi, et al.
Publicado: (2022) -
Efonidipine Inhibits JNK and NF-κB Pathway to Attenuate Inflammation and Cell Migration Induced by Lipopolysaccharide in Microglial Cells
por: Nguyen, Ngoc Minh, et al.
Publicado: (2022) -
Suppression of LPS-Induced Inflammation and Cell Migration by Azelastine through Inhibition of JNK/NF-κB Pathway in BV2 Microglial Cells
por: Nguyen, Phuong Linh, et al.
Publicado: (2021) -
Sonidegib Suppresses Production of Inflammatory Mediators and Cell Migration in BV2 Microglial Cells and Mice Treated with Lipopolysaccharide via JNK and NF-κB Inhibition
por: Nguyen, Ngoc Minh, et al.
Publicado: (2022)