Synthesis, Characterisation and Mechanism of Action of Anticancer 3-Fluoroazetidin-2-ones

The stilbene combretastatin A-4 (CA-4) is a potent microtubule-disrupting agent interacting at the colchicine-binding site of tubulin. In the present work, the synthesis, characterisation and mechanism of action of a series of 3-fluoro and 3,3-difluoro substituted β-lactams as analogues of the tubul...

Descripción completa

Detalles Bibliográficos
Autores principales: Malebari, Azizah M., Duffy Morales, Gabriela, Twamley, Brendan, Fayne, Darren, Khan, Mohemmed Faraz, McLoughlin, Eavan C., O’Boyle, Niamh M., Zisterer, Daniela M., Meegan, Mary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501633/
https://www.ncbi.nlm.nih.gov/pubmed/36145265
http://dx.doi.org/10.3390/ph15091044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501633/
https://www.ncbi.nlm.nih.gov/pubmed/36145265
http://dx.doi.org/10.3390/ph15091044

Ejemplares similares