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Synthesis, Characterisation and Mechanism of Action of Anticancer 3-Fluoroazetidin-2-ones

The stilbene combretastatin A-4 (CA-4) is a potent microtubule-disrupting agent interacting at the colchicine-binding site of tubulin. In the present work, the synthesis, characterisation and mechanism of action of a series of 3-fluoro and 3,3-difluoro substituted β-lactams as analogues of the tubul...

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Detalles Bibliográficos
Autores principales:	Malebari, Azizah M., Duffy Morales, Gabriela, Twamley, Brendan, Fayne, Darren, Khan, Mohemmed Faraz, McLoughlin, Eavan C., O’Boyle, Niamh M., Zisterer, Daniela M., Meegan, Mary J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501633/ https://www.ncbi.nlm.nih.gov/pubmed/36145265 http://dx.doi.org/10.3390/ph15091044

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